A systematic review on application of nano-carriers loaded with drug in the treatment of neurological disorders

The central nervous system disorders represent a worldwide public health problem. Neuro-degeneration is associated with many transitions in brain including synaptic disorder and neuro-cognition decline. It shielded by barrier which controls the entry of compounds into known as blood (BBB), there regulating homeostasis. In achieving therapeutic amount drug to proper site action body then maintaining desired concentration for sufficient time interval be clinically effective treatment. Particularly, neurodegenerative diseases such Parkinson’s disease (PD) Alzheimer’s (AD) are becoming further established elderly inhabitants society. These ailments usually encompass advanced degeneration & neuronal loss, rendering these spread difficult treat. There various types pharmaceutical approaches treat neurological disorders. loaded Nano-carriers one them. this review, we will address different applications treatment developed enhance delivery across BBB include micelles, exosomes, liposomes, nanotubes, nanoparticle, Nano emulsions, dendrimers, gels, quantum dots, etc. recent developments Nano-carriers’ implementation through size/charge optimization surface modifications like PE Gylation, targeting delivery, coating surfactants have been discussed, detailed description Nano-scaled devices employed has also defined. This review provides brief overview variety carriers diagnostic probes delivery.